Effect of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats

نویسندگان

  • Rumyana Simeonova
  • Vessela Vitcheva
  • Mitka Mitcheva
چکیده

Tobacco smoking is a risk factor for variety of cardio-vascular diseases, such as hypertension, myocardial infarction, stroke and many others. It is of great importance for hypertensive patients to stop smoking. One of the medicines widely used for smoking cessation in Bulgaria is the original Bulgarian product Tabex®, which is developed on the basis of natural plant alkaloid cytisine. The aim of the following study was to ivestigate the effects of cytisine on some brain and hepatic biochemical parameters in spontaneously hypertensive rats (SHR), an widely used rodent model for human essential hypertension, and to compare the obtained results with their age-matched normotensive controls Wistar Kyoto (WKY). Multiple cytisine administration did not affect the activity of ethylmorphine-N-demethylase (EMND) and anylinehydroxylase (AH), as well as the quantity of cytochrome P 450, nor in WKY neither in SHR In the liver cytisine increased the MDA quantity both in SHR and in WKY, by 25% (p<0.05) and by 29% (p<0.05) respectively, while the GSH level was not significantly changed by the compound in both strains. In contrast, on the brain level, cytisine administration to SHR caused more prominent toxicity, resulted in GSH depletion and increased MDA quantity, while in WKY strain did not exert any toxicity. Cytisine did not significantly affect ALAT and ASAT activity in both strains. In conclusion, the results of our study suggest higher brain toxicity of cytisine in spontaneously hypertensive rats, that might be due to their pathophysiological characteristics.

برای دانلود رایگان متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Effects of Ramadan fasting on some physiological and biochemical parameters in healthy and hypertensive subjects in Aurangabad district of Maharashtra, India

Throughout the world, millions of Muslims fast daily during the month of Ramadan from sunrise (Sahar) until sunset (Iftar). Considering the impacts of environment on physiological functions, we performed this study in order to examine the effects of Ramadan fasting on some blood parameters of healthy volunteers and hypertensive patients. According to the results, there were no significant chang...

متن کامل

Effect of the aqueous extract of Panax ginseng on the histomorphometric properties of the liver and some serum biochemical parameters of Rainbow trout (Oncorhynchus mykiss)

  Panax ginseng (P. ginseng) root as a traditional herbal medicine, has biological capabilities e.g. antioxidative and detoxification, although there is little data about its probable effects on the liver structure particularly in the aquatic organisms. So, the present study was aimed to investigate the effects of different levels of aqueous extract of P. Ginseng root on the hepatic histomorpho...

متن کامل

Augmented responses to intrathecal nicotinic agonists in spontaneous hypertension.

Abnormal central cholinergic activity has been reported to be responsible in part for the pathogenesis of high blood pressure in spontaneously hypertensive rats (SHR). Administration of cholinergic agonists in brain and spinal cord results in exaggerated pressor responses in SHR. Studies to date have focused largely on the muscarinic cholinergic system. Recently, we demonstrated that intratheca...

متن کامل

Hepato Protective and Antioxidant Role of Berberis tinctoria lesch Leaves on Paracetamol Induced Hepatic Damage in Rats

The scientific evaluation of medicinal plants used in the preparation of folk remedies has provided modern medicine with effective pharmaceuticals for the treatment of diseases. The methanol extract of Berberis tinctoria Lesch (Berberidaceae) leaves was investigated for its hepatoprotective and antioxidant effects on paracetamol (750 mg/kg) induced acute liver damage in Wistar albino rats. Hepa...

متن کامل

Protective Role of Leptadenia Hastata on the Haematological and Biochemical Alterations in Adrenaline-Induced Hypertensive Rats

Background: Leptadenia hastata (L. Hastata) is a plant used for various diseases in Nigeria. This study evaluated the protective effects of L. hastate on the haematological and biochemical alterations in adrenaline-induced hypertensive rats. Methods: Twenty-five rats were divided equally into five groups (A-E). Groups A-D were given 0.5 mg/kg adrenaline, groups A and B were treated with 100 an...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

عنوان ژورنال:

دوره 3  شماره 

صفحات  -

تاریخ انتشار 2010